DB-Fair-3 Injection - (300000IU)

DB-Fair-3 Injection (300,000 IU) is very likely a high-dose vitamin D3 (cholecalciferol) injection used to correct substantial vitamin D deficiency. It’s potent, and while useful, it comes with risks (especially of high calcium), so it should only be used under medical supervision.

DB-Fair-3’s high-dose (300,000 IU) fits into the historical tradition of “mega-dose” vitamin D therapy, which has been used for decades in medicine, especially for deficiency or bone disease.

The historical evidence supports that such large doses, when properly used, can be effective and (relatively) safe, if monitored.

Understanding this history shows why such injections exist: they’re not a “new gimmick” but rather a medically validated approach, especially when oral dosing is inadequate.

History of Vitamin D and High-Dose Vitamin D Therapy

Early Recognition: Rickets

The health problem that led to the discovery of vitamin D was rickets, a bone disease in children, caused by deficiency of a “nutritional factor.”   

Edward Mellanby (a British researcher) was key: he linked a dietary factor to prevention of rickets in the early 20th century.  

Discovery of Vitamin D

Scientists realized that exposure to ultraviolet (UV) light could produce a factor in the skin that cured rickets; this “factor” was later identified as vitamin D.  

In the 1920s, chemical isolation and synthesis of vitamin D started.  

Two main forms were recognized: vitamin D₂ (ergocalciferol) and vitamin D₃ (cholecalciferol).  

Biological Mechanism

Later in the mid-20th century, researchers discovered how vitamin D is metabolized: it is first hydroxylated in the liver (to 25-hydroxyvitamin D), then in the kidney (to the active hormone 1,25-dihydroxyvitamin D₃). 

The active form (1,25-(OH)₂D₃) acts like a steroid hormone, binding to vitamin D receptors (VDR) on cells to regulate genes that control calcium/phosphate balance. 

Development of Therapeutic Vitamin D

Doctors began using vitamin D (both D₂ and D₃) in very large doses to treat bone-mineral disorders. For example, in renal osteodystrophy (a bone disease in kidney failure), doses of 150,000-500,000 IU were historically used, with careful monitoring of calcium and phosphate. 

Over time, clinicians developed injectable forms (intramuscular) of vitamin D3 (cholecalciferol) to deliver large “loading” doses. This is especially useful when oral supplementation is not practical or rapid correction is needed. 

Research has shown that single large doses (e.g., 300,000 IU) administered once can safely raise vitamin D levels in some populations.

Modern Understanding & Safety

By the later 20th century, the understanding of vitamin D “hormone” biology matured, especially with the identification of the active form (1,25-(OH)₂D₃) and its receptor.

Researchers noted that high-dose vitamin D (even in the hundreds of thousands of IU) can be used safely under monitoring, but there is risk (e.g., hypercalcemia), so clinical use requires judgment.

The “history of vitamin D” also includes public health measures: after the discovery, many countries began fortifying foods (like milk) with vitamin D, which dramatically reduced rickets.